protein arginine methyltransferase การใช้

• Methylation of arginine residues is catalyzed by at least two different classes of protein arginine methyltransferase enzymes.
• The HRMT1L2 gene encodes a protein arginine methyltransferase that functions as a histone methyltransferase specific for histone H4.
• The human homolog, which physically interacts with protein arginine methyltransferase 5 ( PRMT5 ), is essential for cell survival.
• Generally, methylation of an arginine residue requires a complex including protein arginine methyltransferase ( PRMT ) while lysine requires a specific histone methyltransferase ( HMT ), usually containing an evolutionarily conserved SET domain.
• In a study purifying cancerous liver cells infected with HBV, the level of expression of protein arginine methyltransferase 1 ( PRMT1 ) was found to be associated with changes in transcription due to the methyltransferase function of PRMT1.